Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Matteo PonzoAnais DebessetMélissande CossuttaMounira Chalabi-DcharClaire HouppeCaroline PilonAlba Nicolas-BoludaSylvain MeunierFabio RaineriAllan ThiolatRemy NicolleFederica MaioneSerena BrunduCarina Florina CojocaruPhilippe BouvetCorinne BousquetFlorence GazeauChristophe TournigandJosé CourtyEnrico GiraudoJosé Laurent CohenIlaria CasconePublished in: Cancers (2022)
These results demonstrate that NCL inhibition blocks the amplification of lymphoid and myeloid immunosuppressive cells and promotes T cell activation in PDAC through a new mechanism of action dependent on the direct inhibition of the tumoral stroma.