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Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.

Matteo PonzoAnais DebessetMélissande CossuttaMounira Chalabi-DcharClaire HouppeCaroline PilonAlba Nicolas-BoludaSylvain MeunierFabio RaineriAllan ThiolatRemy NicolleFederica MaioneSerena BrunduCarina Florina CojocaruPhilippe BouvetCorinne BousquetFlorence GazeauChristophe TournigandJosé CourtyEnrico GiraudoJosé Laurent CohenIlaria Cascone
Published in: Cancers (2022)
These results demonstrate that NCL inhibition blocks the amplification of lymphoid and myeloid immunosuppressive cells and promotes T cell activation in PDAC through a new mechanism of action dependent on the direct inhibition of the tumoral stroma.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • dendritic cells
  • acute myeloid leukemia
  • cancer therapy
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death
  • pi k akt