Immune checkpoint inhibitor-related cholangiopathy: Novel clinicopathological description of a multi-centre cohort.
Philip BerrySreelakshmi KothaYoh ZenSophie PapaTareq El MenabaweyGeorge WebsterDeepak JoshiMichael HeneghanPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Within this heterogeneous cohort, we identified that CPI-related cholangiopathy responded poorly to immunosuppression and potentially progressed to bile duct loss. Thorough radiological and histological assessment is recommended, as identification of the cholangiopathy-associated phenotype may permit more informed advice regarding prognosis. Further data is required to determine detailed immunological characterisation in order to identify individuals at an increased risk of developing cholangiopathy.
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