Breaking bad.

Mohini Bhattacharya Alexander R Horswill

Published in: The Journal of experimental medicine (2023)

DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221086) develop D1-/-, D1L3-/-, and D1-/-D1L3-/- mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms.

Keyphrases

staphylococcus aureus
drug delivery
high fat diet induced
metabolic syndrome
candida albicans
replacement therapy
insulin resistance
escherichia coli
methicillin resistant staphylococcus aureus
adipose tissue