Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy.

Luise AppeltshauserAnna-Michelle BrunderAnnika HeiniusPeter Körtvélyessy Klaus-Peter WandingerRalf JunkerCarmen Villmann Claudia Sommer Christian Schmidt Kathrin Doppler

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

Our data (1) confirm and extend previous observations that antiparanodal IgG2/3 but not IgG4 antibodies can occur in acute-onset neuropathies manifesting as monophasic GBS, (2) suggest association of IgG3 to a favorable response to IVIg, and (3) lend support to the hypothesis that in some patients, an IgG subclass switch from IgG3 to IgG4 may be the correlate of a secondary progressive or relapsing course following a GBS-like onset.

Keyphrases

multiple sclerosis
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intensive care unit
prognostic factors
patient reported outcomes
artificial intelligence