Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer's disease.

Philip Simon John WestonTeresa PooleJennifer M NicholasNicolas ToussaintIvor J A SimpsonMarc ModatNatalie S RyanYuying LiangMartin N RossorJonathan M SchottSebastien OurselinHui ZhangNick C Fox

Published in: Alzheimer's research & therapy (2020)

Cortical MD measurement detects microstructural breakdown in presymptomatic FAD and correlates with proximity to symptom onset independently of cortical thickness. Cortical MD may thus be a feasible biomarker of early AD-related neurodegeneration, offering additional/complementary information to conventional MRI measures.

Keyphrases

white matter
magnetic resonance imaging
molecular dynamics
healthcare
computed tomography
optical coherence tomography
cognitive decline
social media
patient reported