Fast skeletal muscle troponin activator CK-2066260 mitigates skeletal muscle weakness independently of the underlying cause.

Arthur J ChengJennifer StrömDarren T HweeFady I MalikHåkan Westerblad

Published in: Journal of cachexia, sarcopenia and muscle (2020)

The fast skeletal muscle troponin activator CK-2066260 effectively mitigates muscle weakness, especially when it is caused by impaired activation of the myofibrillar contractile machinery due to either decreased sarcoplasmic reticulum Ca2+ release or reduced myofibrillar Ca2+ sensitivity.

Keyphrases

skeletal muscle
protein kinase
insulin resistance
nuclear factor
radiation induced
radiation therapy
metabolic syndrome