Structural and Functional Brain Network Connectivity at Different King's Stages in Patients With Amyotrophic Lateral Sclerosis.
Edoardo Gioele SpinelliAlma GhirelliSilvia BasaiaElisa CanuVeronica CastelnovoCamilla CividiniTommaso RussoParide SchitoYuri Matteo FalzoneNilo RivaMassimo FilippiFederica AgostaPublished in: Neurology (2023)
MRI of the brain allows to demonstrate and quantify increasing disruption of structural connectivity involving the sensorimotor networks in ALS, mirroring disease stages. Frontotemporal functional disconnection seems to characterize only advanced disease phases. Our findings support the utility of MRI connectomics to stratify patients and stage brain pathology in ALS in a reproducible way, which may mirror clinical progression.
Keyphrases
- amyotrophic lateral sclerosis
- resting state
- functional connectivity
- white matter
- magnetic resonance imaging
- end stage renal disease
- contrast enhanced
- newly diagnosed
- ejection fraction
- cerebral ischemia
- chronic kidney disease
- prognostic factors
- computed tomography
- patient reported outcomes
- blood brain barrier
- brain injury