Late-pregnancy dysglycemia in obese pregnancies after negative testing for gestational diabetes and risk of future childhood overweight: An interim analysis from a longitudinal mother-child cohort study.
Delphina GomesRüdiger von KriesMaria DeliusUlrich MansmannMartha NastMartina StubertLena LanghammerNikolaus A HaasHeinrich NetzViola ObermeierStefan KuhleLesca M HoldtDaniel TeupserUwe HasbargenAdelbert A RoscherRegina EnsenauerPublished in: PLoS medicine (2018)
Findings from this interim analysis suggest that offspring of obese mothers treated because of a diagnosis of GDM appeared to have a better BMI outcome in childhood than those of obese mothers who-following negative GDM testing-remained untreated in the last trimester and developed dysglycemia. Late-pregnancy dysglycemia related to uncontrolled weight gain may contribute to the development of child overweight and maternal diabetes. Our data suggest that negative GDM testing in obese pregnancies is not an "all-clear signal" and should not lead to reduced attention and risk awareness of physicians and obese women. Effective strategies are needed to maintain third-trimester glycemic and weight gain control among otherwise healthy obese pregnant women.
Keyphrases
- weight gain
- weight loss
- pregnancy outcomes
- birth weight
- pregnant women
- type diabetes
- adipose tissue
- preterm birth
- body mass index
- bariatric surgery
- metabolic syndrome
- gestational age
- obese patients
- glycemic control
- mental health
- physical activity
- primary care
- working memory
- cardiovascular disease
- high fat diet
- machine learning
- insulin resistance
- early life
- artificial intelligence
- data analysis
- big data