The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study.

Alexander M KulminskiAmisha V BarochiaYury LoikaNalini RaghavachariKonstantin G ArbeevMary K WojczynskiBharat ThyagarajanBadri N VardarajanKaare ChristensenAnatoliy I YashinStewart J Levine

Published in: PloS one (2018)

This study for the first time identifies that the APOE gene is associated with modified lung physiology in women. This suggests that a link may exist between the APOE ε4 allele, female sex, and a reduction in the FEV1/FVC ratio in older individuals.

Keyphrases

cognitive decline
high fat diet
genome wide
physical activity
type diabetes
pregnancy outcomes
metabolic syndrome
mild cognitive impairment
breast cancer risk
genome wide analysis