Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells.

Alejandro Peralta-GarciaMariona Torrens-FontanalsTomasz Maciej StepniewskiJudith Grau-ExpósitoDavid PereaVikram AyinampudiMaria WaldhoerMirjam ZimmermannMaria José Buzón Meritxell Genescà Jana Selent

Published in: International journal of molecular sciences (2021)

Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug.

Keyphrases

sars cov
induced apoptosis
cell cycle arrest
respiratory syndrome coronavirus
high throughput
adverse drug
endoplasmic reticulum stress
drug induced
cell death
emergency department
oxidative stress
risk assessment
cell proliferation
climate change