Scopoletin mitigates maternal separation-induced anxiety-like and depression-like behaviors in male mice through modulation of the Sirt1/NF-κB pathway.
Abdelrahim AlqudahEsam QnaisOmar GammohYousra BseisoMohammed WedyanMohammad AlqudahMuna OqalRawan AbudaloTaher HatahetPublished in: Psychopharmacology (2024)
Scopoletin effectively reverses the adverse behavioral and biochemical effects induced by early-life maternal separation in male mice, suggesting its potential as a therapeutic agent for treating anxiety-like and depression-like behaviors. Modulation of neuroinflammatory pathways and the Sirt1/NF-κB signaling axis is one possible mechanism.
Keyphrases
- early life
- sleep quality
- oxidative stress
- signaling pathway
- depressive symptoms
- lps induced
- diabetic rats
- birth weight
- pi k akt
- pregnancy outcomes
- liquid chromatography
- ischemia reperfusion injury
- nuclear factor
- high glucose
- emergency department
- physical activity
- pregnant women
- body mass index
- drug induced
- inflammatory response
- mass spectrometry
- radiation therapy
- radiation induced
- immune response