Three-dimensional culture in a bioengineered matrix and somatic cell complementation to improve growth and survival of bovine preantral follicles.
Juliana I CandelariaRamon Cesar BotigelliCarly GuiltinanHaizheng ZhongAnna Carolina DenicolPublished in: bioRxiv : the preprint server for biology (2024)
We demonstrate that three-dimensional bioengineered hydrogels could aid in the survival and growth of small bovine preantral follicles. Moreover, bovine embryonic stem cells have the potential to differentiate towards precursors of somatic gonadal cell types, presenting an alternative cell source for preantral follicle co-culture.