Anlotinib Enhances the Therapeutic Effect of Bladder Cancer with GSDMB Expression: Analyzed from TCGA Bladder Cancer Database & Mouse Bladder Cancer Cell Line.

Chen WangQifeng CaoShun ZhangHailong LiuHuangqi DuanWeimin XiaHaibo ShenCheng Wang

Published in: Pharmacogenomics and personalized medicine (2023)

Anlotinib has a strong antitumor effect on GSDMB-positive bladder tumors. This effect is mainly achieved by anlotinib stimulating the secretion of relevant antitumor factors by lymphocytes. The PI3K/AKT and MEK signal transduction pathways were inhibited by Anlotinib in bladder cancer expressing GSDMB protein.

Keyphrases

spinal cord injury
binding protein
muscle invasive bladder cancer
emergency department
cell proliferation
small molecule
amino acid
signaling pathway
long non coding rna
pi k akt
bioinformatics analysis