Effect of chloroquine pre-treatment on the metoclopramide's pharmacokinetics after their co-administration.

Badriyah Shadid AlotaibiIram KaukabSyed Nisar Hussain ShahZelal KharabaAbdul Rafay NaeemHaya YasinMuhammad Ihtisham UmarGhulam Murtaza

Published in: Expert opinion on drug safety (2024)

Chloroquine was found to attenuate CYP2D6 activity in healthy Pakistani male volunteers. Hence, patients that are prescribed with metoclopramide or other CYP2D6-substrate drugs require a dose adjustment when administered with chloroquine.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
plasmodium falciparum
peritoneal dialysis
prognostic factors
combination therapy