Clinical, immunological, and genetic features in 780 patients with autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like diseases: A systematic review.

Nasim Hafezi Majid Zaki-Dizaji Matineh Nirouei Gelayol Asadi Niusha Sharifinejad Mahnaz JameeSeyed Erfan RasouliHaleh HamedifarAraz SabzevariZahra Chavoshzadeh Reza Yazdani Hassan Abolhassani Asghar Aghamohammadi Gholamreza Azizi

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)

Our results showed that the FAS gene with 85% frequency is the main etiological cause of genetically diagnosed patients with ALPS phenotype; therefore, the genetic defect of the majority of suspected ALPS patients could be confirmed by mutation analysis of FAS gene.

Keyphrases

genome wide
copy number
end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
dna methylation
multiple sclerosis
prognostic factors
epstein barr virus
peritoneal dialysis
pulmonary embolism
case report
patient reported outcomes