Cardioprotective effects of pharmacological blockade of the mitochondrial calcium uniporter on myocardial ischemia-reperfusion injury.
Francisco Sandro Menezes-RodriguesJosé Gustavo Padrão TavaresEnio Rodrigues VasquesPaolo Ruggero ErranteErisvaldo Amarante de AraújoMarcelo Pires-OliveiraCarla Alessandra Scorza BahiFulvio Alexandre ScorzaFernanda de Freitas AnibalPaulo Sergio BossiniPublished in: Acta cirurgica brasileira (2020)
The significant reduction of the incidence of CIR-induced VA, AVB and LET produced by the treatment with RuR indicates that the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of MCU can protect the myocardium against injuries caused by CIR.