Binding of [18F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients.

Jolien M SchaeverbekeSofie CelenJulie CornelisAlicja RoniszKim SerdonsKoen Van LaereDietmar Rudolf ThalThomas TousseynGuy BormansRik Vandenberghe

Published in: European journal of nuclear medicine and molecular imaging (2019)

In vitro autoradiography showed no [18F]AV1451 binding in SV PPA due to FTLD-TDP, while specific binding was present in SV PPA due to AD and PiD. The discrepancy between in vitro and in vivo findings remains to be explained. The discordance is not related to [18F]AV1451 idiosyncrasies as [18F]THK5351 findings were similar.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
dna binding
multiple sclerosis
peritoneal dialysis
resting state
brain injury
cerebral ischemia