Discovery of Aburatubolactams Reveals Biosynthetic Logic for Distinct 5/5-Type Polycyclic Tetramate Macrolactams.

Youzhe ChenHongbo JinWeiliang XiongZhuangjie FangWeiguang SunYiguang ZhuLiping ZhangYong-Hui Zhang Wenjun Zhang Changsheng Zhang

Published in: Organic letters (2024)

A known polycyclic tetramate macrolactam (aburatubolactam C, 3 ) and three new ones (aburatubolactams D-F, 4 - 6 , respectively) were isolated from the marine-derived Streptomyces sp. SCSIO 40070. The absolute configuration of 3 was established by X-ray analysis. A combinatorial biosynthetic approach unveiled biosynthetic enzymes dictating the formation of distinct 5/5-type ring systems (such as C 7 -C 14 cyclization by AtlB1 in 5 and C 6 -C 13 cyclization by AtlB2 in 6 ) in aburatubolactams.

Keyphrases

small molecule
high resolution
magnetic resonance
computed tomography
mass spectrometry
data analysis
electron microscopy