Association of Cortical Hyperexcitability and Cognitive Impairment in Patients With Amyotrophic Lateral Sclerosis.
Mana HigashiharaNathan PaveyMehdi A J van den BosParvathi MenonMatthew C KiernanSteve VucicPublished in: Neurology (2021)
Cortical hyperexcitability was more prominent in cognitively impaired patients with ALS than in controls. Given that ECAS is a valid predictor of TDP-43 pathology, the increase in cortical hyperexcitability may be associated with TDP-43 accumulation.