Leptomeningeal relapse in primary cutaneous DLBCL: Implications for a prophylactic CNS therapy.

PCDLBCL leg type is an aggressive malignancy. Molecular/genomic mechanism likely responsible for CNS dissemination should be identified by prospective multi-centric studies that can better define the subsets of patients eligible for prophylactic therapy in the absence of a high CNS-IPI risk.