IDH1-mutated Crohn's disease-associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated-type dysplasia.
Camilla GueriniDaniela FurlanGiuseppina FerrarioFederica GrilloLaura LiberaGiovanni ArpaCatherine KlersyMarco Vincenzo LentiRoberta RiboniEnrico SolciaAngelo Paolo Dei TosLuca MastracciSandro ArdizzoneAnnick MoensGert De HertoghMarc FerranteRondell P GrahamFausto SessaMarco PaulliAntonio Di SabatinoAlessandro VanoliPublished in: Histopathology (2023)
IDH1-mutated CrD-SBAs, which represent approximately one-fifth of total cases, are characterised by distinctive immunophenotypical features and methylation profiles, with potential therapeutic implications. Moreover, IDH1-mutated non-conventional, serrated dysplasia is likely to represent a precursor lesion to such CrD-SBAs.