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Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function.

Fuyi XuAnran ChenShuijing PanYingying WuHongjie HeZhe HanLu LuBuyan-Ochir OrgilXiaoDong ChiCunhua YangShushan JiaCuicui YuJia Mi
Published in: CNS neuroscience & therapeutics (2024)
Our study demonstrated that pain sensitivity is associated with genetic background and Rnf20-mediated PI3K-Akt signaling may involve in the regulation of pain sensitivity and cognitive functions.
Keyphrases
  • chronic pain
  • pi k akt
  • pain management
  • neuropathic pain
  • signaling pathway
  • cell proliferation
  • genome wide
  • cell cycle arrest
  • spinal cord injury
  • copy number
  • spinal cord
  • dna methylation
  • cell death