Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27.

Lu PanJinghua WangJinxiang LiuLishuang GuoSi-Rui Yang

Published in: Rheumatology (Oxford, England) (2021)

Tr1 cells are involved in the pathogenesis of IgAV. The low IL-27 in IgAV is responsible for impaired frequency and function of Tr1 cells, and EGR2 may be the specific transcription factor involved in the progression. Tr1 may be a risk factor for IgAV recurrence.

Keyphrases

induced apoptosis
cell cycle arrest
transcription factor
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress
replacement therapy