Technical development and validation of a clinically applicable microenvironment classifier as a biomarker of tumour hypoxia for soft tissue sarcoma.

Laura J ForkerBecky BibbyLingjian YangBrian LaneJoely IrlamHitesh B MistryMairah KhanHelen ValentineJames WyliePatrick ShenjereMichael LeahyPiers GauntLucinda BillinghamBeatrice M SeddonRob GrimerMartin RobinsonAnanya ChoudhuryCatharine M L West

Published in: British journal of cancer (2023)

This study comprehensively validates a microenvironment classifier befitting FFPE STS biopsies. Future uses include: (1) selecting high-risk patients for perioperative chemotherapy; and (2) biomarker-driven trials of hypoxia-targeted therapies.

Keyphrases

end stage renal disease
stem cells
ejection fraction
endothelial cells
newly diagnosed
chronic kidney disease
cardiac surgery
prognostic factors
squamous cell carcinoma
current status
acute kidney injury
patient reported
locally advanced