Mitotic count is prognostic in IDH-mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trials 26053 and EORTC 22033-26033.

Johan M KrosElisabeth RushingAimé L UwimanaAurelio Hernández-LaínAlex MichotteMaysa Al-HussainiFranck BielleChristian MawrinGianluca MarucciC Mircea S TesileanuRoger StuppBrigitta BaumertMartin van den BentPim J FrenchThierry Gorlia

Published in: Neuro-oncology (2022)

The mitotic index (cut-off 2 per 10 40x HPF) is of prognostic significance in IDHmut astrocytomas without HD CDKN2A/B. Therefore, the mitotic index may direct the therapeutic approach for patients with IDHmut astrocytomas with native CDKN2A/B status.

Keyphrases

cell cycle
wild type
cell proliferation
low grade
clinical practice
peripheral blood
high grade