Antidiarrheal effect of sodium hydrosulfide in diabetic rats: In vitro and in vivo studies.

These findings showed NaHS effectively controlled diarrhea in diabetic rats through decreasing the frequency, and tension of spontaneous contraction of smooth muscles of large, and small intestines. The increased frequency and tension of spontaneous contractions of smooth muscles in diabetic rats may be due to down-regulation of H2 S biosynthesis enzymes.