Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis.

Ana Luísa Fialho de Amaral Areia Miguel AreiaAnabela Mota-Pinto

Published in: Archives of gynecology and obstetrics (2020)

From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28-0.73) and a modest specificity (0.72; 95% CI 0.51-0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53-0.84), but also better specificity (0.75; 95% CI 0.55-0.88), compared with the other inflammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis.

Keyphrases

systematic review
low birth weight
preterm birth
case control
gestational age
oxidative stress
meta analyses
preterm infants
structural basis
protein kinase