Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication.
Kaijing LiuLilija WehlingShan WanSofia M E WeilerMarcell TóthDavid IbbersonSilke MarhenkeAdnan AliMacrina LamTe GuoFederico PinnaFabiola PedriniAmruta Damle-VartakAnne DropmannFabian RoseSilvia ColucciWenxiang ChengMichaela BissingerJennifer SchmittPatrizia BirnerTanja PothPeter AngelSteven DooleyMartina U MuckenthalerThomas LongerichArndt VogelMathias HeikenwälderPeter SchirmacherKai BreuhahnPublished in: Cellular and molecular life sciences : CMLS (2024)
YAP inactivation in HCs and BECs causes liver damage, and concomitant TAZ deletion does not enhance but reduces this phenotype. Additionally, we present a new mechanism by which YAP contributes to cell-cell communication originating from NPCs.