Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function.

Thikryat NeamatallahShilan JabbarRothwelle TateJuliane SchroederMuhannad ShweashJames AlexanderRobin Plevin

Published in: International journal of molecular sciences (2019)

Transcriptome profiling reveals that MKP-2 regulates macrophage development showing candidate targets from monocyte-to-macrophage differentiation and macrophage proliferation. However, it is unclear whether effects upon ERK signalling are able to explain the effects of DUSP-4 deletion on macrophage function.

Keyphrases

gene expression
adipose tissue
signaling pathway
dna methylation
single cell
cell proliferation
dendritic cells
endothelial cells
protein kinase
pi k akt