Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy.
Noam LevinBiman C PariaNolan R ValeRami YossefFrank J LoweryMaria R ParkhurstZhiya YuMaria FlorentinGal CafriJared J GartnerMackenzie L ShindorfLien T NgoSatyajit RaySanghyun P KimAmy R CopelandPaul F RobbinsSteven A RosenbergPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The TCR library directed against RAS hotspot mutations described here recognize RAS mutations found in about 45% of the Caucasian population and about 60% of the Asian population and represent promising reagents for "off-the-shelf" ACTs.