Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.
Peggi M AngelLaura S SpruillMelanie JeffersonJennifer R BethardLauren E BallChanita Hughes HalbertRichard R DrakePublished in: The Prostate (2020)
Site-specific posttranslational regulation of collagen structure by proline hydroxylation may be involved in reactive stroma associated with PCa progression. Translational and posttranslational regulation of collagen protein structure has potential for new markers to understand PCa progression and outcomes.
Keyphrases
- mass spectrometry
- high resolution
- wound healing
- papillary thyroid
- prostate cancer
- type diabetes
- liquid chromatography
- risk assessment
- metabolic syndrome
- adipose tissue
- radical prostatectomy
- capillary electrophoresis
- skeletal muscle
- high performance liquid chromatography
- squamous cell
- amino acid
- climate change
- small molecule
- insulin resistance
- binding protein
- human health
- tandem mass spectrometry