A Nanostructured Protein Filtration Device for Possible Use in the Treatment of Alzheimer's Disease-Concept and Feasibility after In Vivo Tests.

Thomas Gabriel Schreiner Menéndez-González Manuel Maricel Adam Bogdan Ovidiu Popescu Andrei Szilagyi Gabriela-Dumitrita Stanciu Bogdan Ionel TambaRomeo Cristian Ciobanu

Published in: Bioengineering (Basel, Switzerland) (2023)

We demonstrated that a nanoporous ceramic filter-based system that filtrates Aβ from the cerebrospinal fluid is a feasible and safe treatment modality in the AD mouse model. The presented prototype has a functional lifespan of around four weeks, highlighting the need to develop advanced nanoporous ceramic filters with anti-biofouling properties to ensure the long-term action of this therapy.

Keyphrases

mouse model
cerebrospinal fluid
combination therapy
small molecule
mesenchymal stem cells
mild cognitive impairment
smoking cessation