Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration.
Dibyadeep DattaIsabella PeroneDenethi WijegunawardanaFeng LiangYury M MorozovJon ArellanoAlvaro DuqueZhongcong XieChristopher H van DyckMary Kate P JoyceAmy F T ArnstenPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
These data help to explain why pT217-tau predicts degeneration in AD and how it gains access to CSF and plasma to serve as a fluid biomarker.
Keyphrases
- prefrontal cortex
- early stage
- cerebrospinal fluid
- high resolution
- electronic health record
- big data
- atomic force microscopy
- sentinel lymph node
- squamous cell carcinoma
- radiation therapy
- mass spectrometry
- machine learning
- working memory
- photodynamic therapy
- deep learning
- data analysis
- high speed
- artificial intelligence