Green Synthesis of Liquid Metal-Doped Carbon Dots for Treating Multidrug-Resistant Gram-Negative Bacteria.
Shunchao BiChen HangJie QiWei ZhangXingyu JiangPublished in: Advanced biology (2023)
Global emergence of multidrug-resistant (MDR) gram-negative bacteria triggers severe infections that result in an epidemic. It is urgent to discover novel classes of antibacterial agents. Here, a green route for synthesizing polyethylene glycol-based carbon dots (PEG-CDs) doped with liquid metal (LM-Cdots) via a solvent-free system is presented. LM-Cdots synthesized via ultrasound exhibit great antibacterial activity against gram-negative bacteria (E. coli, P. aeruginosa, K. pneumoniae, and A. baumannii) and their multidrug-resistant (MDR) clinical isolates. In the in vitro antibacterial test with MDR K. pneumoniae, LM-Cdots show an extremely low minimum inhibition concentration (MIC) of 0.63 µg mL -1 . Compared to naked PEG-CDs, the MIC is improved by 1000 times. In vivo results reveal that LM-Cdots can accelerate wound healing with low biotoxicity and inflammation.
Keyphrases
- multidrug resistant
- quantum dots
- drug resistant
- wound healing
- gram negative
- acinetobacter baumannii
- visible light
- silver nanoparticles
- ionic liquid
- klebsiella pneumoniae
- drug delivery
- oxidative stress
- escherichia coli
- highly efficient
- early onset
- metal organic framework
- computed tomography
- essential oil
- pseudomonas aeruginosa
- contrast enhanced ultrasound
- cystic fibrosis