Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease.

Thomas W Earnest Abdalla BaniSung Min HaDiana A HobbsDeydeep KothapalliBraden Yang John J Lee Tammie L S Benzinger Brian A Gordon Aristeidis Sotirasnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

NMF reveals patterns of tau deposition in AD. Data-driven staging of flortaucipir tracks AD severity. Learned flortaucipir patterns overlap with AD-related gene expression.

Keyphrases

gene expression
lymph node
pet ct
dna methylation
cognitive decline
cerebrospinal fluid
drug induced