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Therapeutic Strategies and Chemoprevention of Atherosclerosis: What Do We Know and Where Do We Go?

Ana Clara AprotosoaieAlexandru-Dan CostacheIrina-Iuliana Costache
Published in: Pharmaceutics (2022)
Despite progress in understanding the pathogenesis of atherosclerosis, the development of effective therapeutic strategies is a challenging task that requires more research to attain its full potential. This review discusses current pharmacotherapy in atherosclerosis and explores the potential of some important emerging therapies (antibody-based therapeutics, cytokine-targeting therapy, antisense oligonucleotides, photodynamic therapy and theranostics) in terms of clinical translation. A chemopreventive approach based on modern research of plant-derived products is also presented. Future perspectives on preventive and therapeutic management of atherosclerosis and the design of tailored treatments are outlined.
Keyphrases
  • cardiovascular disease
  • photodynamic therapy
  • smoking cessation
  • small molecule
  • stem cells
  • type diabetes
  • nucleic acid
  • drug delivery
  • cell wall