Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model.
Pierre-Simon BellayeAlexandra OudotJean-Marc VrigneaudOlivier RaguinFrancis BichatAnne VaslinHélène Maby-El HajjamiClaudio ZannaGrégoire VuagniauxPierre FumoleauFranck DenatFrançois BrunotteBertrand CollinPublished in: Contrast media & molecular imaging (2018)
This imaging study combining SPECT and PET showed the early proapoptotic effects of Debio 1143 resulting in a robust antitumor activity in a preclinical TNBC model. These imaging biomarkers represent valuable noninvasive tools for translational and clinical research in TNBC.