Intralesional photodynamic therapy induces apoptosis in basal cell carcinoma and Bowen's disease through caspase 3 and granzyme B.

G EvangelouDimitra KoumakiI FragiadakiV ChaniotisM D FarrarC KaratziElena SotiriouE GiannikakiAlexander C KatoulisM PapadakisAimillios LallasM StefanidouS Krueger-KrasagakisLesley E RhodesK Krasagakis

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

Intralesional PDT induces apoptosis in BCC and Bowen's disease via common and alternative apoptotic pathways involving granzyme B. Proapoptotic factors Bak in both BCC and Bowen and Bax in Bowen's disease appear to increase by intralesional PDT at 24 hours.

Keyphrases

photodynamic therapy
cell death
basal cell carcinoma
induced apoptosis
signaling pathway
endoplasmic reticulum stress