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The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats.

Keshab Kumar KarnaBo Ram ChoiJae Hyung YouYu Seob ShinWan Shou CuiSung Won LeeJi Hoon KimChul Young KimHye Kyung KimJong Kwan Park
Published in: BMC complementary and alternative medicine (2019)
This study suggests that the crosstalk between oxidative stress, ER stress, and mitochondrial pathway mediates varicocele-induced testicular germ cell apoptosis. MAS promotes spermatogenesis in varicocele-induced SD rat, probably by decreasing cytokines (IL-6, TNF-α) levels, regulating abnormal sex hormones, and decreasing oxidative stress, ER stress, and apoptosis.
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