Ca 2+ -sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress.

Wei ChenMadeline M MotsingerJiaqian LiKevin P Bohannon Phyllis I Hanson

Published in: bioRxiv : the preprint server for biology (2024)

-sensor ALG-2, play a critical role in stabilizing the lysosomal membrane against osmotically-induced rupture. This finding suggests that cells have mechanisms not just for repairing but also for actively protecting lysosomes from stress-induced membrane damage.

Keyphrases

stress induced
induced apoptosis
cell cycle arrest
diabetic rats
signaling pathway
cell proliferation
endoplasmic reticulum stress
drug induced