Hybrid Composite of Silver Nanoparticle-Porous Silicon Microparticles as an Image-Guided Localization Agent for Computed Tomography Scan of the Lungs.
Eun Mi LeeJiyeon LeeYejin KimKyung Sik YiJanggeun ChoJaehoon KimJong Min AnDahae LeeSung Joon KimEunkyung AnYoo Jin HongHyejung JoSeo Hyeon LeeYuna JungChi-Hoon ChoiJae Seung KangJin HurDokyoung KimPublished in: ACS biomaterials science & engineering (2020)
A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytical equipment, including a scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The hybrid composite showed a high CT contrast intensity (>1000 HU) that enabled us to produce and view images of the lungs. In addition, it showed the ability to maintain a strong CT signal at the injected area of the rabbit's lungs, up to an hour, without spreading. The lack of toxicity and immune response indicated that the composite could be fully utilized as a new image-guided localization agent of CT scans for lung cancer surgery.
Keyphrases
- dual energy
- computed tomography
- silver nanoparticles
- image quality
- contrast enhanced
- high resolution
- positron emission tomography
- magnetic resonance imaging
- electron microscopy
- immune response
- gold nanoparticles
- magnetic resonance
- single molecule
- machine learning
- oxidative stress
- inflammatory response
- liquid chromatography
- ionic liquid
- high intensity
- acute coronary syndrome
- solid state
- molecularly imprinted