NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma.

Dongli YueShasha LiuTengfei ZhangYong WangGuohui QinXinfeng ChenHuanyu ZhangDong WangDong HuangFeng WangLiping WangSong ZhaoYi Zhang

Published in: Cancer biology & medicine (2021)

As a marker of ESCC, NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor, suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
signaling pathway
epithelial mesenchymal transition
cell proliferation
transcription factor
pi k akt
cell death
squamous cell carcinoma
young adults