NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma.
Dongli YueShasha LiuTengfei ZhangYong WangGuohui QinXinfeng ChenHuanyu ZhangDong WangDong HuangFeng WangLiping WangSong ZhaoYi ZhangPublished in: Cancer biology & medicine (2021)
As a marker of ESCC, NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor, suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC.