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NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma.

Dongli YueShasha LiuTengfei ZhangYong WangGuohui QinXinfeng ChenHuanyu ZhangDong WangDong HuangFeng WangLiping WangSong ZhaoYi Zhang
Published in: Cancer biology & medicine (2021)
As a marker of ESCC, NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor, suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • stem cells
  • signaling pathway
  • epithelial mesenchymal transition
  • cell proliferation
  • transcription factor
  • pi k akt
  • cell death
  • squamous cell carcinoma
  • young adults