Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study.
Karoline Aebi-PoppChristian R KahlertPierre-Alex CrisinelLaurent Arthur DecosterdSusana Alves SaldanhaIrene HoesliBegona Martinez De TejadaAndrea DuppenthalerAndri RauchCatia Marzolininull nullPublished in: The Journal of antimicrobial chemotherapy (2022)
ARVs were transferred to a variable extent in breastmilk. Nevertheless, the estimated daily ARV dose from breastfeeding remained low. Differential ARV exposure was observed in breastfed infants with some ARVs being below/above their effective concentrations raising the concern of resistance development if HIV infection occurs. More data on this potential risk are warranted to better support breastfeeding.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- preterm infants
- men who have sex with men
- hiv testing
- mental health
- hepatitis c virus
- physical activity
- electronic health record
- south africa
- big data
- human health
- risk assessment
- machine learning
- deep learning
- drug induced