Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.
Jérémy FerrierMathilde Bayet-RobertRomain DalmannAbderrahim El GuerrabYoussef AissouniDanielle Graveron-DemillyMaryse ChalusJérémy PinguetAlain EschalierDamien RichardLaurence DaulhacFabien MarchandDavid BalayssacPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Our study describes a decrease in cholinergic neurotransmission in the posterior insular cortex in neuropathic pain condition and the involvement of M2 receptors. Targeting these cortical muscarinic M2 receptors using central cholinomimetics could be an effective therapy for neuropathic pain treatment.