Encapsulation for Cancer Therapy.
Xavier MontanéAnna BajekKrzysztof RoszkowskiJosep M MontornésMarta GiamberiniSzymon RoszkowskiOliwia KowalczykRicard Garcia-VallsBartosz TylkowskiPublished in: Molecules (Basel, Switzerland) (2020)
The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems-inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations-offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted.
Keyphrases
- drug delivery
- cancer therapy
- drug release
- papillary thyroid
- squamous cell
- loop mediated isothermal amplification
- carbon nanotubes
- squamous cell carcinoma
- lymph node metastasis
- real time pcr
- electronic health record
- drug induced
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry
- replacement therapy