Calcium-activated potassium channels as amplifiers of TRPV4-mediated pulmonary edema formation in male mice.
Mei LiJuliana RoederJorge Blázquez-PrietoSabrina SchulzJulia NaujoxMaría Pía HolgadoLasti ErfinandaWolfgang B LiedtkeGuillermo M AlbaicetaWolfgang M KueblerLaura MichalickPublished in: Anesthesiology (2024)
KCa channels, specifically IK1, act as amplifiers of TRPV4-mediated Ca2+ influx and establish a detrimental feedback that promotes barrier failure and drives the progression of VILI.