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Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance.

Fang JiChang WangHuimin WangGuangliang LiuBolei ChenLi-Gang HuGuibin JiangMaoyong SongYong Liang
Published in: Chemical communications (Cambridge, England) (2018)
We report here the antimicrobial ability of tetrabromobisphenol A (TBBPA) against Gram-positive bacteria without detectable resistance. Microscopy imaging and gene analysis reveal that the bacterial cell wall is the target of TBBPA. Structure-activity studies of TBBPA and its analogues relate the observed antimicrobial activity to the halogen substitution neighboring the phenolic hydroxyl group.
Keyphrases
  • cell wall
  • gram negative
  • high resolution
  • genome wide
  • staphylococcus aureus
  • multidrug resistant
  • single molecule
  • copy number
  • molecular docking
  • optical coherence tomography
  • high speed
  • gene expression