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Genetic Modifiers in Neurodegeneration.

Nimansha JainAlice S Chen-Plotkin
Published in: Current genetic medicine reports (2018)
Here, we summarize the literature reporting genetic modifier effects in HD, FTLD, AD, and PD. We further contextualize reported genetic modifier effects in these diseases in terms of insight they may lend to the concept of a polygenic landscape for the major neurodegenerative diseases.
Keyphrases
  • genome wide
  • systematic review
  • copy number
  • emergency department
  • gene expression