Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma.
Sama IzadpanahParastoo ShabaniAli Aghebati-MalekiAmir BaghbanzadehAli FotouhiAmir BisadiLeili Aghebati MalekiBehzad BaradaranPublished in: Journal of cellular physiology (2019)
Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS-CSCs play a key role in the resistance to treatment and relapse and metastasis through self-renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell-phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS.
Keyphrases
- cancer stem cells
- induced apoptosis
- signaling pathway
- squamous cell carcinoma
- minimally invasive
- small cell lung cancer
- oxidative stress
- cardiovascular disease
- type diabetes
- coronary artery disease
- locally advanced
- cell cycle arrest
- postmenopausal women
- rectal cancer
- acute coronary syndrome
- current status
- bone regeneration