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Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.

Nicole Elisabeth Ørsted SchultzHenrik HasseldamRune Skovgaard RasmussenNina VindegaardOskar McWilliamHelle Klingenberg IversenFlemming Fryd Johansen
Published in: Neurological research (2018)
Stroke induces changes in the RhoA-ROCK pathway in T-cells. CRP and NIHSS score correlated positively in the study. Statins may have an anti-inflammatory effect as statin treatment before stroke reduces post-stroke pro-inflammatory levels. RhoA GTPase and its downstream effectors are possibly the key to improve statin treatment in stroke.
Keyphrases
  • atrial fibrillation
  • cardiovascular disease
  • coronary artery disease
  • anti inflammatory
  • type diabetes
  • combination therapy
  • cerebral ischemia